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Multiple Choice Questions « Return to contents list Chapter 12, Question 1.1. Hormonal systems are commonly characterized by feedback inhibition. In contrast to hormones, many cytokines amplify responses by upregulation of their own receptors on target cells. An example of this mechanism is seen in which of the following? a. the differential cytokine expression of TH1 and TH2 cells. b. the chemokine concentration gradient resulting in chemotaxis. c. the stimulation of CD4+ T cells by IL-2. d. the effect of cytokines on osteoblastic differentiation.